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Alzheimer's disease is a devastating illness. People with Alzheimer's\nsuffer from progressive memory loss, cognition impairment, physical\ndeterioration and eventual death. Current treatment methods can slow\ndisease progression, but they do not stop or prevent it.

\n

Recent studies have shown that medical marijuana may help with\nAlzheimer's symptoms, slow progression and provide some prevention.

\n

Alzheimer's and the Brain

\n

Alzheimer's disease is the most common form of dementia in the United\nStates. The Alzheimer's\nAssociation\nestimates that in 2015, 5.3 million Americans will have Alzheimer's. It\nis the sixth leading cause of death in total, and is responsible for\n32% of\ndeaths\nin adults 65 and older in the United States.

\n

In Alzheimer's, protein plaques, called beta-amyloids, build up between\nthe nerve cells, particularly those responsible for memory and\ncognition. The plaques disrupt cell communication leading to loss of\nfunction. Additionally, tau proteins form tangled fibers inside the\nbrain cells, preventing nutrients from reaching the cells. Both\nabnormalities eventually cause cell death.

\n

Alzheimer's may also affect the cannabinoid system in the body.\nEndocannabinoids,\nnaturally occurring chemicals in the body, interact with cannabinoid\nreceptors in the brain and immune system and are responsible for\nhomeostasis.\nResearch shows\nthat Parkinson's disease, Huntington's disease and multiple sclerosis -\nall neurodegenerative disorders similar to Alzheimer's - reduce\ncannabinoid system function. These reductions cause many of the symptoms\nof these illnesses, including anxiety, sleeplessness, and appetite loss.

\n

Cannabis and the Brain

\n

About 150 years ago, medical marijuana was introduced in England to\ntreat a number of conditions, including senile dementia. In 1890, Sir J.\nRussell Reynolds, physician to Queen Victoria, wrote in\nLancet that\nhe \"found nothing comparable in utility to a moderate dose of Indian\nhemp,\" or marijuana, for treating senile insomnia.

\n

Due to its chemical composition and effects on the brain, cannabis\nshould be studied with regards to Alzheimer's. Recent\nstudies\nhave found that the cannabinoids in marijuana, particularly\ndelta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), successfully\nstimulate appetite, improve sleep and reduce anxiety in Alzheimer's\npatients.

\n

Cannabis may also help slow disease progression. Iuvone et\nal. found that CBD reduces\nthe inflammation associated with Alzheimer's. Eubanks, et\nal.,\nfound that THC inhibits the buildup of amyloid plaques, and does so\nbetter than the Alzheimer's drugs donepezil and tacrine. They also found\nthat cannabis interferes with neurotransmitter degradation and may halt\nthe formation of tau fiber tangles, which has potential preventative\nimplications.

\n

Conclusion

\n

Research is just beginning regarding the benefits of treating\nAlzheimer's patients with cannabis, but these early findings are\npromising and provide direction for further study.

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