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Crohn's Disease is an autoimmune disease that results in chronic\ninflammation of the gastrointestinal (GI) tract. It generally affects\nthe beginning of the large intestine and the lower section of the small\nbowel. Symptoms of Crohn's Disease include persistent diarrhea,\nabdominal pain and intestinal obstruction, occasionally combined with\nrectal bleeding. Some two-thirds of patients with Crohn's will require\nsurgery at some point during their lifetime to reduce their symptoms.

\n

New Research Suggests Medical Marijuana Can Help

\n

Dr. Jeffrey Hergenrather recently published research in the journal\nClinical Gastroenterology and\nHepatology\nthat suggests that medical marijuana may offer relief to certain\npatients with Crohn's disease. Because patients with Crohn's or\nirritable bowel disease (IBD) have high levels of endocannabinoid\nreceptors in their GI tract, Hergenrather wondered if the cannabinoids\nin marijuana could reduce their inflammation.

\n

In his study, published in 2013, Hergenrather found that 10 out of 11\npatients who were treated with medical marijuana had \"significant\nreduction in symptoms.\" Five of those patients experienced a complete\nremission of the disease.

\n

\"This has a huge effect on patients with Crohn's disease,\" said\nHergenrather in an interview\nwith\nO'Shaugnessy's.\nHe originally conceived of the study in 2000 when he compared notes with\nother clinicians about the effects medical marijuana was having on their\npatients. \"We noticed right off that people were saying cannabis was\nworking for Crohn's Disease,\" he says.

\n

The Science Behind the Cure

\n

Cannabis acts on receptors in the brain called CB1 and CB2, which are\nprotein molecules that change their shape when they encounter a chemical\nstimulus. Stimulation of CB1 and CB2 receptors causes changes in brain\nand body function. CB1 and CB2 are receptors that change their shape when\nthey encounter cannabinoids like THC. This process occurs in the GI\ntract when medical marijuana is used. Due to the fact that both CB1 and\nCB2 cannabinoid receptors are found in the digestive system, medical\nmarijuana is particularly promising as a treatment regimen for patients\nwith digestive disorders. When medical marijuana activates CB1 receptors\nintestinal movement is decreased, which can potentially help treat\npersistent diarrhea. When CB2 cannabinoid receptors are activated by\nmedical marijuana, they decrease the production of the immune cells\nresponsible for inflammation. Additionally, THC has been shown to help\nreduce fluid leakage through the lining of the GI tract.

\n

While edibles are not always ideal for patients with Crohn's, due to the\nsensitivity of their stomachs, they are the fastest way to get\ncannabinoids to the receptors in the GI tract. Alternative delivery\nmethods patients with Crohn's can use are sublingual oils, vaporization,\nand smoking.

\n

Photo Credit.

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