{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/ibd/","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_12316-markdown","title":"Can CBD help with GI issues? ","slug":"can-cbd-help-with-gi-issues","content":"\"Specifically IBS, IBD, and GERD?\"\n_____________________\nHi there!\n\nThe endocannabinoid system (ECS) is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies—especially those that have few, if any, effective pharmocotherapeutic interventions, such as celiac disease, MS, fibromyalgia, IBD and IBS. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CEDC. CBD works by balancing and supporting the ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that modulate serotonin, GABA, dopamine, and many more.\nIn IBD and GERD, inflammation is central to both the etiology and symptomology of the respective disease. CBD is well known as an effective immunomodulator and anti-inflammatory, and those properties still do apply to GI inflammation. However, unique to the GI tract, are specialized nerve cells called enteric glial cells— \"the glue of the nteric nervous system (ENS)\"—which, when overactive, also contribute to acute and chronic GI inflammation. Recent pre-clinical research suggests that CBD may lower GI inflammation by controlling reactive gliosis in the ENS. Or, in other words, CBD restores homeostasis in the gut by reducing hyperactivity in enteric glial cells.\n\ndrkim\n_____________________\nThe ENS is an extensive network of neurons supported by enteric glial cells (the above mentioned \"glue\" on the ENS). Two neural plexuses comprise the ENS: the myenteric plexus, involved in motility/peristalsis; and the submucosal plexus, involved in intestinal and gastric secretions. CBD works to restores homeostasis in the ENS via modulation of enteric glial cells (as mentioned above), the myenteric plexus, and the submucosal plexus.\n\nAlthough inflammation plays little, if any, role in the pathology of IBS, CBD's balancing of the myenteric plexus lessens inappropriate and painful intestinal contractions; while balancing of the submucosal plexus reduces inappropriate gastric and intestinal secretions. CBD's effects on glial cells, the submucosal plexus and myenteric plexus factor into CBD's ability to alleviate symptoms of GERD, IBS and IBD.\n\nAn ongoing, randomized, placebo controlled, double-blind, cross-over trial has shown chewable CBD to significantly reduce IBS-related pain. To be included in the study, it was also necessary that patients experienced, according to their own account, at least three pain episodes per week of a predefined intensity. All patients who participated in the study experienced decrease in their levels of pain score. On top of the overall reduction, the trend curve suggests 50% higher pain reduction.\n\ndrkim\n_____________________\nFurthermore, several studies show that among patients who seek medical attention for IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have psychiatric comorbidity—depression and generalized anxiety disorder being most common. CBD increases serotonin signaling at the 5-HT1A receptor—the same neurotransmitter and receptor that SSRIs like Prozac influence—which is mostly why CBD has antidepressant and anxiolytic properties. In fact, SSRIs and tricyclic antidepressants (which also increase serotonin signalling), have been shown to alleviate anxiety and depression symptoms, as well as alleviate some of the abdominal pain and bowel symptoms involved in IBS, IBD and gastroesophageal reflux disease (GERD), which is why SSRIs and TCAs are commonly prescribed for IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12315-markdown","title":"Can CBD help with GI issues?","slug":"can-cbd-help-with-gi-issues-1","content":"\"Like IBS, IBD and GERD?\"\n_____________________\nHi there!\nThe endocannabinoid system (ECS) is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies—especially those that have few, if any, effective pharmocotherapeutic interventions, such as celiac disease, MS, fibromyalgia, IBD and IBS. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CEDC. CBD works by balancing and supporting the ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that modulate serotonin, GABA, dopamine, and many more.\n\nIn IBD and GERD, inflammation is central to both the etiology and symptomology of the respective disease. CBD is well known as an effective immunomodulator and anti-inflammatory, and those properties still do apply to GI inflammation. However, unique to the GI tract, are specialized nerve cells called enteric glial cells— \"the glue of the enteric nervous system (ENS)\"—which, when overactive, also contribute to acute and chronic GI inflammation. Recent pre-clinical research suggests that CBD may lower GI inflammation by controlling reactive gliosis in the ENS. Or, in other words, CBD restores homeostasis in the gut by reducing hyperactivity in enteric glial cells.\n\ndrkim\n_____________________\nThe enteric ENS is an extensive network of neurons supported by enteric glial cells (the above mentioned \"glue\" on the ENS). Two neural plexuses comprise the ENS: the myenteric plexus, involved in motility/peristalsis; and the submucosal plexus, involved in intestinal and gastric secretions. CBD works to restores homeostasis in the ENS via modulation of enteric glial cells (as mentioned above), the myenteric plexus, and the submucosal plexus.\n\nAlthough inflammation plays little, if any, role in the pathology of IBS, CBD's balancing of the myenteric plexus lessens inappropriate and painful intestinal contractions; while balancing of the submucosal plexus reduces inappropriate gastric and intestinal secretions. CBD's effects on glial cells, the submucosal plexus and myenteric plexus factor into CBD's ability to alleviate symptoms of GERD, IBS and IBD.\n\nAn ongoing, randomized, placebo controlled, double-blind, cross-over trial has shown chewable CBD to significantly reduce IBS-related pain. To be included in the study, it was also necessary that patients experienced, according to their own account, at least three pain episodes per week of a predefined intensity. All patients who participated in the study experienced decrease in their levels of pain score. On top of the overall reduction, the trend curve suggests 50% higher pain reduction.\n\ndrkim\n_____________________\nFurthermore, several studies show that among patients who seek medical attention for IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have psychiatric comorbidity—depression and generalized anxiety disorder being most common. CBD increases serotonin signaling at the 5-HT1A receptor—the same neurotransmitter and receptor that SSRIs like Prozac influence—which is mostly why CBD has antidepressant and anxiolytic properties. In fact, SSRIs and tricyclic antidepressants (which also increase serotonin signalling), have been shown to alleviate anxiety and depression symptoms, as well as alleviate some of the abdominal pain and bowel symptoms involved in IBS, IBD and gastroesophageal reflux disease (GERD), which is why SSRIs and TCAs are commonly prescribed for IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_11788-markdown","title":"IBD and CBD","slug":"ibd-and-cbd","content":"\"Hello my 10year old daughter has IBD-UC and we want to avoid pharmaceuticals.  would love to hear from others about their experience with CBD products to decrease inflammation from autoimmune diseases, especially IBD.  thank you\"\n_____________________\nHello,\nActivating cannabinoid receptors has been demonstrated to inhibit gastrointestinal fluid secretion and inflammation in animal models. Several studies indicate that cannabinoids in marijuana bind with cannabinoid receptors in the digestive tract, especially the small and large intestine.\n\nFurthermore, both CBD and THC have been shown to reduce the inflammatory response in patients with autoimmune diseases, such as multiple sclerosis, lupus and celiac disease; both CBD and THC have  also been shown to help alleviate pain.  However, it is mainly THC, rather than CBD, that helps alleviate nausea and stimulate the appetite.\n\n\"CBD may interact at extra-cannabinoid system receptor sites, such as  peroxisome proliferator-activated receptor-gamma. This strategic  interaction makes CBD as a potential candidate for the development of a  new class of anti-IBD drugs.\"\nhttps://www.ncbi.nlm.nih.gov/pubmed/22815234\n\n\"CBD targets enteric reactive gliosis, counteracts the inflammatory  environment ... in human colonic cultures derived from UC patients. These actions lead to a reduction of intestinal damage. Our results therefore  indicate that CBD indeed unravels a new therapeutic strategy to treat  inflammatory bowel diseases.\"\nhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028159\n\ndrkim\n_____________________\nHello! I agree with Dr. Kim's very nice answer. Since your daughter is 10, I would recommend she try CBD rich products since they are less psychoactive. CBD is a powerful antiinflammatory compound, which often helps with inflammatory bowel diseases. A tiny bit of THC helps the CBD to work more effectively. I might suggest you try a ratio of at least 12:1 CBD to THC in a sublingual tincture. Start with a couple drops and observe the effects. You can increase the dose if necessary over time. Hope this helps. Best of luck.\n\ndrjacquelynlew","image":null}},{"node":{"id":"Question_7708-markdown","title":"Does smoking marijuana cause worsening of Irritable Bowel Disease (IBD) symptoms?  ","slug":"does-smoking-marijuana-cause-worsening-of-irritable-bowel-disease-ibd-symptoms","content":"\"Will smoking marijuana cause flare ups? I know that smoking cigarettes does.\"\n_____________________\nIrritable bowel syndrome is a chronic condition of the digestive system.  Symptoms are abdominal pain and altered bowel habits such as constipation and diarrhea. Many studies have shown that THC reduces intestinal motility which is the spontaneous movement of the bowel. THC  alleviates colonic spasms and abdominal pain in IBS suffers. IBS is one of the few conditions that the state of New York allows to be treated by medical marijuana.\n\nhelenanp","image":null}}]}},"pageContext":{"limit":12,"skip":0,"numPages":1,"currentPage":1,"id":5368,"name":"IBD","slug":"ibd","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}