{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/osteoporosis/","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_11892-markdown","title":"which product would be best for bone building - I have osteoporosis","slug":"which-product-would-be-best-for-bone-building-i-have-osteoporosis","content":"\n_____________________\nHello, \nThere is a significant amount of pre-clinical research regarding the endocannabinoid system's (ECS) role in balancing the formation and resorption of bone.\n\nInterestingly, when the Cannabinoid Receptor 1 (CB1) or Cannabinoid Receptor 2 (CB2) is deactivated, bone formation was favored in younger mice. However, in elderly mice, CB1 or CB2 receptor deactivation resulted in accelerated bone loss.\nhttps://www.ncbi.nlm.nih.gov/pubmed/21358974\n\nThis makes sense as the ECS is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium).\nAs animals grow, bone formation is, of course, favored over resorption. Accordingly, when the ECS' homeostatic influence was removed from young mice -- via CB1 or CB2 receptor deactivation -- excessive formation was the result. \n\nHowever, in the elderly, bone resorption is favored over formation. Accordingly, when the ECS' homeostatic influence was removed at this stage, accelerated bone loss was the result. These findings suggest that cannabis may be useful in slowing the progression of osteoporosis.\nhttps://www.ncbi.nlm.nih.gov/pubmed/19634029\n\ndrkim\n_____________________\nBased on the research above, the mechanism of action involved cannabinoids binding the CB1 and mostly CB2 receptors; THC binds the CB1 and CB2 receptors with high affinity, while CBD has very little interaction with CB1 and CB2 receptors. Therefore, I would recommend products which contain THC. However, I cannot give you specific recommendations without gathering a complete history. Please consult with a physician before starting any cannabis treatment regimen. \n\ndrkim","image":null}},{"node":{"id":"Question_11843-markdown","title":"What is the best CBD product for osteoporosis","slug":"what-is-the-best-cbd-product-for-osteoporosis","content":"\n_____________________\nHello,\nI could not find literature specifically mentioning CBD in regards to osteoporosis. However, there is a significant amount of pre-clinical research describing the endocannabinoid system's (ECS) role in balancing the formation and resorption of bone.\n\nInterestingly, when the Cannabinoid receptor 1 (CB1) or Cannabinoid receptor 2 (CB2) is deactivated, bone formation was favored in younger mice. However, in older mice, CB1 or CB2 receptor deactivation resulted in accelerated bone loss.\nhttps://www.ncbi.nlm.nih.gov/pubmed/21358974\n\nThis makes sense as the ECS' role is largely devoted to homeostasis ().When we are young, our body is building bone. So when the ECS' homeostatic influence is removed -- via CB1 or CB2 receptor deactivation -- excessive formation is the result.\n\nContrastingly, because bone resorption is favored over bone formation later in life, removal of the ECS' homeostatic influence resulted in accelerated bone loss in elderly mice. These results suggest that cannabis may help slow the progression of osteoporosis.\n\n\ndrkim\n_____________________\nHello,\nI could not find any literature specifically mentioning CBD in regards to osteoporosis. However, there is a significant amount of pre-clinical research regarding the endocannabinoid system's (ECS) role in balancing the formation and resorption of bone.\n\nInterestingly, when the Cannabinoid Receptor 1 (CB1) or Cannabinoid Receptor 2 (CB2) is deactivated, bone formation was favored in younger mice. However, in elderly mice, CB1 or CB2 receptor deactivation resulted in accelerated bone loss.\nhttps://www.ncbi.nlm.nih.gov/pubmed/21358974\n\nThis makes sense as the ECS is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium).\nAs animals grow, bone formation is, of course, favored over resorption. Accordingly, when the ECS' homeostatic influence was removed from young mice -- via CB1 or CB2 receptor deactivation -- excessive formation was the result. However, in the elderly, bone resorption is favored over formation. Accordingly, when the ECS' homeostatic influence was removed at this stage, accelerated bone loss was the result. These findings suggest that cannabis may be useful in slowing the progression of osteoporosis. \nhttps://www.ncbi.nlm.nih.gov/pubmed/19634029\n\ndrkim\n_____________________\nthank you so much for your research. I am 68 so I think my osteoporosis, Hashimoto's and arthritis could be helped with CBD. I also have  I would really appreciate information on what form, what strength, what dosage ....\n\nchangis","image":null}},{"node":{"id":"Question_7971-markdown","title":"Does cannabis help osteoporosis, and if so, in what way? ","slug":"does-cannabis-help-osteoporosis-and-if-so-in-what-way","content":"\"Would I eventually be able to stop taking Fosamax?\"\n_____________________\nThere are cannabinoid receptors on bone cells that BUILD bone, which would in theory help with bone density.  However, there aren't studies that can demonstrate how much effect it has on osteoporosis in humans, so it's hard to say if cannabis could replace a medicine like Fosamax.\n\ndrbultman","image":null}},{"node":{"id":"Question_7883-markdown","title":"Can marijuana help with degenerative osteoporosis in the back and neck?","slug":"can-marijuana-help-with-degenerative-osteoporosis-in-the-back-and-neck","content":"\"What type of cannabis product should I be using?\"\n_____________________\nIn preclinical studies CBD regulates the bone cells and shift the energy into making bone vs breaking bone down. Since it takes many years to show a benefit I don't have any clinical cases to report. CBD would also stop the bone pain because it is highly effective as an analgesic.\n\ndrblair","image":null}},{"node":{"id":"Question_10014-markdown","title":"Is CBD beneficial in healing bone fractures and preventing osteoporosis?","slug":"is-cbd-beneficial-in-healing-bone-fractures-and-preventing-osteoporosis","content":"\n_____________________\nYes, CBD's due appear beneficial in supporting healthy bone function. It appears that CBD slows the action of the osteoclasts (the part of the bone that reabsorbs the bone cells) and it may increase the osteoblasts (the part of the bone that forms new bone cells) by regulating bone activity. \nDeficiency of CB1 may cause osteoporosis by increasing bone reabsorption and reducing new bone formation.  The CB2 receptors are believed to maintain a healthy balance of bone resorption and new bone formation, protecting against age related osteoporosis. \n Topical CBDs are beneficial for pain but since the topical CBD will not go systemic so I am not aware of it being used in preventing osteoporosis, an oral or inhaled form of CBD may produce far better results.\n\ndrolson","image":null}}]}},"pageContext":{"limit":12,"skip":0,"numPages":1,"currentPage":1,"id":5594,"name":"Osteoporosis","slug":"osteoporosis","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}