{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/research/3","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_11241-markdown","title":"I have read that THC (RSO) is not absorbed when using it in a suppository. Some doctors say it is not absorbed","slug":"i-have-read-that-thc-rso-is-not-absorbed-when-using-it-in-a-suppository-some-doctors-say-it-is-not-absorbed","content":"\"I did not get a direct answer when I asked earlier.  My husband has brain cancer and I read two articles by Dr. Allan Frankel, MD who states it does not work.  Dr Mahmoud ElSohly of NIDA in Mississippi, who is involved daily in the study of cannabis medicines, makes it clear that years of research in their labs shows that cannabis oil is not absorbed rectally. This is very important to me because of the cost of the concentrated THC as well as I want it to be absorbed.  Look at:  Dr Mahmoud ElSohly of NIDA in Mississippi, who is involved daily in the study of cannabis medicines, makes it clear that years of research in their labs shows that cannabis oil is not absorbed rectally. Some sources:  http://www.greenbridgemed.com/latest-thoughts-on-rectal-administration/ OR http://www.greenbridgemed.com/rectal-absorption-of-cannabinoids/  OR http://www.sciencedirect.com/science/article/pii/0091305791903534.  Please advise.\"\n_____________________\nI used (RSO) cannabis for stage 4 Prostate cancer. It was absorbed very well and after 33 days PSA went from 96 to 2.9. follow up CT and PET scans showed no cancer. I completed the 60 day regiment as recommended with no side affects\n\nsaltydog\n_____________________\nCannabis oil is absorbed rectally. Since there are 3 drainage systems in the rectum, the Superior veins drain towards the liver and the cannabis is metabolized and the Middle and Inferior veins drain directly into the venous system and avoid the \"first pass metabolism\" of the liver. Please re-read Dr. Frankel article as he says the same thing. A very good article from NIDA that describes this also is here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689518/   on item 2.1.4 for rectal absorbtion as well as other methods of administration.\n\nAs for RSO specifically, I cannot comment since I have not read anything directly comparing that to other types of cannabis formulations. However given that it a full spectrum formulation with  THC levels at about 50-60% and CBD at about 10-15%, I would think there would be absorption if given rectally.\n\nPerry Solomon, MD","image":null}},{"node":{"id":"Question_10957-markdown","title":"I'm confused an would like to know a doctor's opinion. Is schizophrenia somehow linked to cannabis use?","slug":"im-confused-an-would-like-to-know-a-doctors-opinion-is-schizophrenia-somehow-linked-to-cannabis-use","content":"\"I have heard that using marijuana can cause schizophrenia and i have heard the opposite. Is there any new or reputable research that shows the two are somehow linked?\"\n_____________________\nAnswer: People genetically pre-disposed to Schizophrenia used cannabis more often...\n\nA study, led by King's College London, and published in the scholarly journal Molecular Psychiatry (Nov 2014), suggests that previous researchers may have misunderstood the dynamic linking marijuana and schizophrenia entirely. \n\n“Studies have consistently shown a link between cannabis use and schizophrenia,” according to lead author Robert Power, from the MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre at the Institute of Psychiatry at King's College, \"We wanted to explore whether this is because of a direct cause and effect, or whether there may be shared genes which predispose individuals to both cannabis use and schizophrenia.\"\n\nThe study examined 2,082 healthy individuals, including 1,011 who'd previously used cannabis. For each participant, a 'genetic risk profile' was measured, based on the number of genes related to schizophrenia they carried. The findings showed that those genetically pre-disposed to schizophrenia used cannabis more often, and in greater quantities than those without schizophrenia risk genes.\n\n“Our study certainly does not rule out that cannabis increases the risk of schizophrenia,” according to Powers. “But it suggests that there is likely to be an association in the other direction as well -- that a predisposition to schizophrenia also increases your likelihood of cannabis use. Our study also highlights the complex interactions between genes and environments when we talk about cannabis as a risk factor for schizophrenia. Certain environmental risks, such as cannabis use, may be more likely given an individual's innate behavior and personality, itself influenced by their genetic make-up. This is an important finding to consider when calculating the economic and health impact of cannabis.\"\n\nOriginal Article:\n\nMolecular Psychiatry 19, 1201-1204 (November 2014) | doi:10.1038/mp.2014.51\n\nGenetic predisposition to schizophrenia associated with increased use of cannabis\n\nR A Power, K J H Verweij, M Zuhair, G W Montgomery, A K Henders, A C Heath, P A F Madden, S E Medland, N R Wray and N G Martin\n\ndrpinto","image":null}},{"node":{"id":"Question_10918-markdown","title":"Is the rectal usage of Hemp Oil - any good?","slug":"is-the-rectal-usage-of-hemp-oil-any-good","content":"\"Rectal usage of Hemp Oil / Rick Simpson Oil (with high THC) is recommended a lot because of various advantages (higher absorption and lesser high). Because of these advantages, my brother in law is taking the oil now via 'the back door' since he has stage 4 cancer. \n\nThough recommended on some sites, I also read on another side that some research has been done and that actually THC Delta 9 does not get absorbed by rectal usage (see the following link http://www.greenbridgemed.com/rectal-absorption-of-cannabinoids/#comment-19565)\n\nThe MD on this forum first claims that rectal usage is great, however later on he advises that indeed rectal administration does not work. \n\nSince we are fighting cancer, we would like to know for sure if rectal usage is advised or not. \n\nIf you could advise, that would be great!!\n\nRegards, \n\nRobbert Roelofsen\"\n_____________________\nYes cannabis can be absorbed rectally. I do not have experience with this method of cannabis administration, but many people are talking about the benefits of rectal cannabis. A larger percentage of the cannabinoids will be absorbed rectally than will be absorbed orally. I would utilize caution as the effects may be quite strong!\n\nandrewvanmd","image":null}},{"node":{"id":"Question_10775-markdown","title":"How to approach my doctor about using medical marijuana for crohns remission","slug":"how-to-approach-my-doctor-about-using-medical-marijuana-for-crohns-remission","content":"\"My son was diagnosed with crohns in 2011.  He was mostly symptom free until December 2015 when he took an antibiotic for strep throat which led to a severe flare.  He was prescribed 60mg of prednisone and placed on Remicade infusions.  The infusions/pred made him feel awful, and he wasn't getting better.  The pain was terrible and he was taking oxycodone just to get through the day.  When the pain was more than he could take, we would make trips to the ER and spend 5-6 days in the hospital at a time trying to get the inflammation under control.  Finally on April 15th of this year, he had surgery.  Now we are wondering what to do to keep the crohns in remission.  He doesn't want to do the Remicade anymore, and he is absolutely done with steroids.  He has done a lot of research on medical marijuana and crohns, but doesn't know how to approach the subject with his doctor.  It is something he wants to try, but doesn't think his doctor will be on board with it.\"\n_____________________\nDoctor's tend to like data, and a literature search on Crohn's disease and cannabis will reveal an abundance of data supporting cannabis for the treatment of Crohn's disease. You might want to bring in an article written for the lay-person that references several studies, such as \"Worth repeating: medical mairjuana defeat's Crohn's disease\" published in SF Gate on March 12, 2016. \n\nAs this article points out, there have been several studies using cellular, animal, and human models indicating that marijuana may not only be used for treating the symptoms of Crohn's disease (such as cramping, pain, and nausea) but may also reverse the disease process by modulating the immune system and decreasing inflammation. As a result, many patients have been able to wean off corticosteroids, opiates, and anti-inflammatory drugs and even potentially prevent surgeries necessitated by disease.\n\ndredmunds","image":null}},{"node":{"id":"Question_10676-markdown","title":"Can MMJ help me with subtle but yet insomnia causing pain on my left knee?","slug":"can-mmj-help-me-with-subtle-but-yet-insomnia-causing-pain-on-my-left-knee","content":"\"1 yr ago i fell off my skateboard in some freak accident, it ended up me landing on my left knee right on a sidewalk curb. Crazy thing is i decided not to go the hospital that same night so i let it heal on its own, and so it did luckily, i can run, walk, and even play sports but sometimes at night i experience minor pain on my left knee, causing discomfort and insomnia in most cases due to the fact that the pain keeps me awake. I've gone to the doctor several times and all they do is prescribe sleep aids and pain relievers. I myself do not believe in pills, so i went the alternative route to do my research on this. I just turned 18 and im wondering if i can really benefit from this?, because when it comes to pills, it relieves one symptom and has potential to cause more harm as the labels require to state the side effects. Im lost, please help? Thank you ! \"\n_____________________\nMany times there are no physical signs of injury after a fall etc., but pain can continue for no obvious cause. This can be seen especially at night when the distractions of the day are gone and you can concentrate on your body.\nFor people who have localized pain, some localized treatment can help that specific area. There are many topical ointments, lotions or salves that can contain cannabinoids that can be applied to a localized area that just work locally without any psychoactive effects. The higher CBD concentrated ointments can target the CB2 receptors in the joints to just help the pain. Use of trans-dermal patch can lead to some psychoactive effects however.\nWhen the pain that is causing lack of sleep is gone, most people find that sleep is easy to find.\n\n\nPerry Solomon, MD","image":null}}]}},"pageContext":{"limit":12,"skip":24,"numPages":3,"currentPage":3,"id":5696,"name":"Research","slug":"research","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}