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"Does Cannabis have interactions with medications Amitriptyline and Propranolol? If so what are that are the side affects? Can it be taken at the same time? "
All three items (cannabinoids like CBD & THC) as well as amitryptylline & propranalol are all metabolized by an enzyme in the liver known as CYP2D6. The drug monographs for both propranolol & amitriptyline already warn that both of these medications used together can cause high plasma levels of the amitryptylline because of down-regulation of said enzyme. Cannabis, in the literature, has also been shown to decrease function of this enzyme & theoretically, this could also increase the plasma amitriptyline levels (although this was just in an experimental lab setting). I would bring these issues up to your primary MD and let them make any needed drug adjustments. I hope this helps!
drpark
Hello, You can safely take cannabis with both amitriptyline and propanolol. Cannabis can increase the serum levels of certain medications -- including amitriptyline and propanolol -- that are metabolized by a network of liver enzymes called the Cytochome P450 system. However, that effect would only occur if taking exorbitant amounts of cannabis -- likely well over 300mg/day.
drkim